Group and individual variability in speech production networks during delayed auditory feedback

Altering reafferent sensory information can have a profound effect on motor output. Introducing a short delay [delayed auditory feedback (DAF)] during speech production results in modulations of voice and loudness, and produces a range of speech dysfluencies. The ability of speakers to resist the effects of delayed feedback is variable yet it is unclear what neural processes underlie differences in susceptibility to DAF. Here, susceptibility to DAF is investigated by looking at the neural basis of within and between subject changes in speech fluency under 50 and 200 ms delay conditions. Using functional magnetic resonance imaging, networks involved in producing speech under two levels of DAF were identified, lying largely within networks active during normal speech production. Independent of condition, fluency ratings were associated with midbrain activity corresponding to periaqueductal grey matter. Across subject variability in ability to produce normal sounding speech under a 200 ms delay was associated with activity in ventral sensorimotor cortices, whereas ability to produce normal sounding speech under a 50 ms delay was associated with left inferior frontal gyrus activity. These data indicate whilst overlapping cortical mechanisms are engaged for speaking under different delay conditions, susceptibility to different temporal delays in speech feedback may involve different process

Direct measurement of diurnal polar motion by ring laser gyroscopes

We report the first direct measurements of the very small effect of forced diurnal polar motion, successfully observed on three of our large ring lasers, which now measure the instantaneous direction of Earth's rotation axis to a precision of 1 part in 10^8 when averaged over a time interval of several hours. Ring laser gyroscopes provide a new viable technique for directly and continuously measuring the position of the instantaneous rotation axis of the Earth and the amplitudes of the Oppolzer modes. In contrast, the space geodetic techniques (VLBI, SLR, GPS, etc.) contain no information about the position of the instantaneous axis of rotation of the Earth, but are sensitive to the complete transformation matrix between the Earth-fixed and inertial reference frame. Further improvements of gyroscopes will provide a powerful new tool for studying the Earth's interior.Comment: 5 pages, 4 figures, agu2001.cl

The AMSC mobile satellite system

The American Mobile Satellite Consortium (AMSC) Mobile Satellite Service (MSS) system is described. AMSC will use three multi-beam satellites to provide L-band MSS coverage to the United States, Canada and Mexico. The AMSC MSS system will have several noteworthy features, including a priority assignment processor that will ensure preemptive access to emergency services, a flexible SCPC channel scheme that will support a wide diversity of services, enlarged system capacity through frequency and orbit reuse, and high effective satellite transmitted power. Each AMSC satellite will make use of 14 MHz (bi-directional) of L-band spectrum. The Ku-band will be used for feeder links

Mobile satellite service in the United States

Mobile satellite service (MSS) has been under development in the United States for more than two decades. The service will soon be provided on a commercial basis by a consortium of eight U.S. companies called the American Mobile Satellite Consortium (AMSC). AMSC will build a three-satellite MSS system that will offer superior performance, reliability and cost effectiveness for organizations requiring mobile communications across the U.S. The development and operation of MSS in North America is being coordinated with Telesat Canada and Mexico. AMSC expects NASA to provide launch services in exchange for capacity on the first AMSC satellite for MSAT-X activities and for government demonstrations

Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1

We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays. Each peptide module in the branched structure makes unique contributions to affinity and/or specificity resulting in a 200 nM affinity ligand that efficiently immunoprecipitates Akt from cancer cell lysates and labels Akt in fixed cells. Our use of a small molecule to preinhibit Akt prior to screening resulted in low micromolar inhibitory potency and an allosteric mode of inhibition, which is evidenced through a series of competitive enzyme kinetic assays. To demonstrate the efficiency and selectivity of the protein-templated in situ click reaction, we developed a novel QPCR-based methodology that enabled a quantitative assessment of its yield. These results point to the potential for iterative in situ click chemistry to generate potent, synthetically accessible antibody replacements with novel inhibitory properties

Optioneering analysis for connecting Dogger Bank offshore wind farms to the GB electricity network

This paper outlines possibilities for connecting 2.4 GW of power from two separate wind farms at Dogger Bank in the North Sea to the GB transmission system in Great Britain. Three options based on HVDC with Voltage Source Converters (VSC HVDC) are investigated: two separate point-to-point connections, a four-terminal multi-terminal network and a four-terminal network with the addition of an AC auxiliary cable between the two wind farms. Each option is investigated in terms of investment cost, controllability and reliability against expected fault scenarios. The paper concludes that a VSC-HVDC point-to-point connection is the cheapest option in terms of capital cost and has the additional advantage that it uses technology that is commercially available. However, while multi-terminal connections are more expensive to build it is found that they can offer significant advantages over point to point systems in terms of security of supply and so could offer better value for money overall. A multi-terminal option with an auxiliary AC connection between wind farms is found to be lower cost than a full multi-terminal DC grid option although the latter network would offer ability to operate at greater connection distances between substations

Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora

Objective: The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth ( 6434 weeks of gestation) among women with bacterial vaginosis or intermediate flora. Study Design: Two hundred eighteen afebrile women in preterm labor with intact membranes had a vaginal Gram stain performed, and sialidase, prolidase, and anti-Gvh IgA concentrations were determined. Results: Women with bacterial vaginosis or intermediate flora had significantly higher sialidase and prolidase concentrations than women with normal flora. Among women with bacterial vaginosis or intermediate flora, the women with sialidase had a higher rate of early preterm birth (P =.05). Sialidase had a sensitivity of 43% and specificity of 77% for early preterm birth. Prolidase and anti-Gvh IgA did not predict early preterm birth. Conclusion: Women in preterm labor with bacterial vaginosis or intermediate flora and detectable sialidase are at increased risk of early preterm birth

Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study

Previous studies have established a role for premotor cortex in the processing of auditory emotional vocalizations. Inhibitory continuous theta burst transcranial magnetic stimulation (cTBS) applied to right premotor cortex selectively increases the reaction time to a same-different task, implying a causal role for right ventral premotor cortex (PMv) in the processing of emotional sounds. However, little is known about the functional networks to which PMv contribute across the cortical hemispheres. In light of these data, the present study aimed to investigate how and where in the brain cTBS affects activity during the processing of auditory emotional vocalizations. Using functional neuroimaging, we report that inhibitory cTBS applied to the right premotor cortex (compared to vertex control site) results in three distinct response profiles: following stimulation of PMv, widespread frontoparietal cortices, including a site close to the target site, and parahippocampal gyrus displayed an increase in activity, whereas the reverse response profile was apparent in a set of midline structures and right IFG. A third response profile was seen in left supramarginal gyrus in which activity was greater post-stimulation at both stimulation sites. Finally, whilst previous studies have shown a condition specific behavioral effect following cTBS to premotor cortex, we did not find a condition specific neural change in BOLD response. These data demonstrate a complex relationship between cTBS and activity in widespread neural networks and are discussed in relation to both emotional processing and the neural basis of cTBS

Tidal Response of Mars Constrained From Laboratory-Based Viscoelastic Dissipation Models and Geophysical Data

We employ laboratory-based grain-size- and temperature-sensitive rheological models to 16 describe the viscoelastic behavior of terrestrial bodies with focus on Mars. Shear modulus 17 reduction and attenuation related to viscoelastic relaxation occur as a result of diffusion- 18 and dislocation-related creep and grain-boundary processes. We consider five rheological 19 models, including extended Burgers, Andrade, Sundberg-Cooper, a power-law approxima- 20 tion, and Maxwell, and determine Martian tidal response. However, the question of which 21 model provides the most appropriate description of dissipation in planetary bodies, re- 22 mains an open issue. To examine this, crust and mantle models (density and elasticity) are 23 computed self-consistently through phase equilibrium calculations as a function of pres- 24 sure, temperature, and bulk composition, whereas core properties are based on an Fe-FeS 25 parameterisation. We assess the compatibility of the viscoelastic models by inverting the 26 available geophysical data for Mars (tidal response and mean density and moment of in- 27 ertia) for temperature, elastic, and attenuation structure. Our results show that although 28 all viscoelastic models are consistent with data, their predictions for the tidal response at 29 other periods and harmonic degrees are distinct. The results also show that Maxwell is 30 only capable of fitting data for unrealistically low viscosities. Our approach can be used 31 quantitatively to distinguish between the viscoelastic models from seismic and/or tidal ob- 32 servations that will allow for improved constraints on interior structure (e.g., with InSight). 33 Finally, the methodology presented here is generally formulated and applicable to other so- 34 lar and extra-solar system bodies where the study of tidal dissipation presents an important 35 means for determining interior structure